eNOS Gene Variants in Recurrent Miscarriage

This study genotyped six eNOS polymorphisms in 200 North Indian women with unexplained recurrent miscarriage and 300 fertile controls. Three variants—12862A>G, Glu298Asp, and intron 4 VNTR (aa genotype)—significantly increased miscarriage risk. Haplotype analysis identified two protective and one high-risk haplotype, suggesting that altered nitric oxide–related vascular regulation contributes to pregnancy loss susceptibility.