Detoxification Gene Variants in Recurrent Miscarriage
Molecular Human Reproduction· 2009· 34 citations
A case-control genetic study evaluating CYP1A1, CYP2D6, GSTM1, GSTT1, and GSTP1 polymorphisms in unexplained recurrent miscarriage.
This case–control study examined phase I (CYP1A1, CYP2D6) and phase II (GSTM1, GSTT1, GSTP1) detoxification gene polymorphisms in 200 North Indian women with unexplained recurrent miscarriage and 300 matched controls. Wild-type CYP1A1 and CYP2D6 genotypes showed protective effects, while the GSTT1 null genotype—and combined high-risk phase I/II variants—significantly increased susceptibility to recurrent miscarriage.
Figure 1. Distribution of phase I and II detoxification gene variants among RM patients and controls.
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